New Drug Boosts Survival in Major Skin Cancer Study

Researchers have scored the first big win against melanoma, the deadliest form of skin cancer. An experimental drug significantly improved survival in a major study of people with very advanced disease. The results, reported Saturday at a cancer conference, left doctors elated.
"We have not had any therapy that has prolonged survival" until now, said Dr. Lynn Schuchter of the Abramson Cancer Center at the University of Pennsylvania, a skin cancer specialist.

The drug, ipilimumab, (ip-ee-LIM-uh-mab), works by helping the immune system fight tumors. The federal Food and Drug Administration has pledged a quick review, and doctors think the drug could be available by the end of this year.
"People are going to have a lot of hope and want this drug, and it's not on their doctors' shelves," although some may be able to get it through special programs directly from its maker, Bristol-Myers Squibb Co., Schuchter said. Melanoma is the most serious form of skin cancer. Last year in the United States, there were about 68,720 new cases and 8,650 deaths from the disease. Worldwide, more than 50,000 people die of melanoma each year.

"The incidence is rising faster than any other cancer," said one of the study's leaders, Dr. Stephen Hodi of Dana-Farber Cancer Institute in Boston. "When it spreads to vital organs, it's almost always fatal."
Doctors also reported Saturday at the conference that an experimental drug for lung cancer patients with a certain gene showed extraordinary promise in early testing. The drug, Pfizer Inc.'s crizotinib, (crih-ZAH-tin-ib) targets a gene that promotes tumour growth and is found in about 4 per cent of lung cancers, especially among younger, non-smokers. Nearly 220,000 new cases of lung cancer are diagnosed each year in the United States alone, and it is the world's top cancer killer. Two other gene-targeted treatments, Tarceva and Iressa, help about 20,000 lung cancer patients annually in the U.S.

The skin cancer study involved 676 people around the world with advanced, inoperable melanoma who had already tried other treatments — a very grim situation. They were given one of three treatments: ipilimumab by itself, with another immune-stimulating treatment, or the immune-stimulating treatment alone. After two years, 24 per cent of those given the drug alone or in combination were alive, versus 14 per cent of those given just the immune-stimulating treatment.
Average survival was 10 months with ipilimumab versus just more than six months for the others, which worked out to a 67 per cent improvement in survival for those on the drug, said one of the study's leaders, Dr. Steven O'Day of the Angeles Clinic and Research Institute in Los Angeles.
Doctors hope the drug can provide more benefit if given earlier in the course of the disease and to less sick patients. Ten per cent to 15 per cent of patients on ipilimumab had serious side effects related to the drug's actions on the immune system. Most were treatable with high doses of steroids.

Every day brings new developments. There are cures for many types of cancer now and new ones every year. Keep your hope alive. Chances are good your cancer can be cured. Just don't expect a magic pill to be developed that cures all cancers. There are so very many types of cancer and each one has to be researched separately.