Three people died and more than 260 were injured in the blasts.
Lawyers for Tazhayakov argued another friend of Mr Tsarnaev's, Dias Kadyrbayev, was responsible for removing the items from a dorm room at the University of Massachusetts-Dartmouth, where Tazhayakov and Mr Tsarnaev were students.Prosecutors, meanwhile, argued both men, who hail from Kazakhstan, were responsible for the decision to destroy the items, including altered fireworks, to protect Mr Tsarnaev.
The backpack and fireworks - emptied of their explosive powder - were later found in a Massachusetts landfill. Mr Kadyrbayev faces a trial in September, while a third friend, US citizen Robel Phillipos, has been charged with lying to investigators in connection with the matter.
Mr Tsarnaev - who faces the death penalty if convicted - will stand trial in November.
He has pleaded not guilty to 30 charges, of which 17 carry the possibility of capital punishment.
Prosecutors allege Mr Tsarnaev set off two pressure cooker bombs with his older brother Tamerlan, who later died in a police shoot-out. Mr Tsarnaev will be charged under the federal death penalty law; Massachusetts abolished the use of capital punishment in 1984.
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